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Lifetime-threatening respiratory despair and Demise have transpired in children who obtained codeine. Codeine is subject matter to variability in metabolism based mostly upon CYP2D6 genotype (explained underneath), which can lead to a heightened exposure into the Energetic metabolite morphine. Primarily based on article-promoting experiences, little ones more youthful than 12 a long time outdated look like far more liable to the respiratory depressant outcomes of codeine, significantly if you will discover possibility factors for respiratory depression.
sufferers who will be allergic to promethazine, any on the ingredients in promethazine, or to other phenothiazines
Concomitant administration of promethazine items with other respiratory depressants has an Affiliation with respiratory despair, and from time to time Demise, in pediatric sufferers.
Prevention and control of nausea and vomiting affiliated with specific types of anesthesia and surgical procedures.
There is absolutely no standard settlement about particular pharmacological treatment method regimens for uncomplicated NMS.
If this SPL includes inactivated NDCs mentioned with the FDA initiated compliance motion, they will be specified therefore.
It is actually strongly proposed that an correct measuring machine be applied. A pharmacist can offer an proper system and can provide Directions for measuring the right dose.
sedation, relief of anxiousness, and manufacture of gentle snooze from which the affected individual can be very easily aroused
Due to chance of respiratory despair, stay away from using opioid antitussives, which includes Promethazine HCl and Codeine Phosphate Oral Remedy in sufferers with compromised respiratory purpose, patients susceptible to respiratory failure, and in aged, cachectic, or debilitated sufferers.
Keep away from the use of get more info Promethazine HCl and Codeine Phosphate Oral Solution in adolescents 12 to 18 years of age who produce other risk things that could raise their sensitivity on the respiratory depressant results of codeine Except if the advantages outweigh the challenges.
This swift conversion ends in larger than expected serum morphine concentrations. Even at labeled dosage regiments, individuals who are ultra-swift metabolizers may well working experience overdose indications like extreme sleepiness, confusion, and shallow respiratory.
Right evaluation in the client, proper prescribing methods, periodic re-evaluation of therapy, and appropriate dispensing and storage are appropriate measures that assist to Restrict abuse of opioid medicine.
Sedating medicines may perhaps lead to confusion and over-sedation while in the aged; aged patients typically really should be started on minimal doses of Promethazine HCl Oral Option and noticed closely.